Webb15 feb. 2024 · circPTEN1结合Smad4进而拮抗Smad复合物的形成和入核 北京大学基础医学院2024级硕士研究生郑林和梁会副研究员为共同第一作者。 北京大学系统生物医学研究所尹玉新教授和基础医学院病理系梁会副研究员为共同通讯作者。 Webb13 apr. 2024 · Using pooled lentiviral sgRNA libraries, we conducted genome-wide loss-of-function screens in Cas9-expressing colorectal and pancreatic cancer cells harboring altered or wild-type SMAD4. The small GTPase protein RAB10 was identified and validated as a susceptibility gene in SMAD4-altered colorectal and pancreatic cancer cells.
Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal …
Webb13 nov. 2024 · Smad contains a series of proteins with similar structures, which are the main signal transducer in transforming growth factors β (TGF-b) superfamily. Specifically, they play an important role in the regulation of cell development and growth. One mechanism of Smads promoting TGF-b-induced cell arrest is down-regulation of Myc, a … Webb12 apr. 2024 · Noninvasive screening by cfDNA holds great promise for multi-cancer early detection. The technology has demonstrated promising results in detecting multiple types of cancer at an early stage. The technology has shown exceptional sensitivity, achieving a 91.1% performance rate based on a 95% specificity and a high level of accuracy, with an … city chevrolet columbia city used cars
SMAD3 promotes expression and activity of the androgen …
WebbThe tumor-suppressing function of SMAD4 is frequently subverted during mammary tumorigenesis, leading to cancer growth, invasion, and metastasis. A long-standing concept is that SMAD4 is not regulated by phosphorylation but ubiquitination. Our search for signaling pathways regulated by breast tumor kinase ... WebbSMAD4: Inactivation of one copy of the SMAD4 gene results in an increased risk of gastric and colorectal cancer (Juvenile Polyposis Syndrome; JPS; Hereditary Hemorrhagic Telangietasia; HHT). 17 probes cover all 12 SMAD4 exons in NM_005359.5. Two of these probes are located in the putative dicrim thann