Radicikol
TīmeklisRadicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). … TīmeklisRadicicol is an inhibitor of heat shock protein 90 (Hsp90; IC 50 = <1 mM). 1,2 It inhibits p23 from associating with Hsp90, suppresses signaling through HIF-1α, and decreases levels of progesterone receptor, Raf-1, p185 erb82, and mutant p53. 3,4 Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an …
Radicikol
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Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Skatīt vairāk Biosynthesis of Radicicol has been best studied in Pochonia chlamydosporia, in which the majority of the core structure is produced in vivo through iterative type I polyketide synthases. This structure produced is the … Skatīt vairāk • Geldanamycin Skatīt vairāk • Winssinger N, Barluanga S (January 2007). "Chemistry and biology of resorcylic acid lactones". Chem Commun. 13 (1): 22–36. doi:10.1039/B610344H. PMID 17279252. … Skatīt vairāk Tīmeklis2024. gada 25. sept. · AdipoGen社のRadicicol (CAS: 12772-57-5)です。AdipoGen社は高品質な低分子化合物，希少な抗生物質，天然物などを販売しています。生理活性 …
Tīmeklis2024. gada 12. apr. · La capacidad de geldanamicina y radicicol para inhibir GRP94 es definitivamente importante desde el punto de vista médico, ya que se utilizan en el tratamiento de tumores malignos. Sin embargo, debido a que son inhibidores de pan-HSP90, estos medicamentos inhiben no solo a los clientes de HSP90 como las … TīmeklisRadicicol is an inhibitor of Hsp90 with an IC50 value PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs …
TīmeklisRadicicol is an antifungal macrolactone antibiotic that is found in Diheterospora chlamydosporia, Chaetomium chiversii, and Monosporium bonorden. It functions as … Tīmeklis2011. gada 29. jūl. · Radicicol at 1 μM alone had little effect on the activation of caspases but at 5 μM it induced the caspase activation apparently. Radicicol at these concentrations significantly enhanced TRAIL-induced caspase activation in both cell lines. The combined effect of TRAIL and radicicol was greater than the sum of each …
TīmeklisRadicicol C18H17ClO6 CID 6323491 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ...
Tīmeklis图2 Radicicol，AT13387，化合物1，PU-H71，KUNB31的结构. Hsp90α和Hspβ亚型选择性抑制剂的设计极具挑战性，因为两种亚型在N端ATP结合位点上的同源性大 … tin of hamTīmeklisRadicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti … tin of ham buildingTīmeklisThe fat mass and obesity-associated protein (FTO), as an m6A demethylase, is involved in many human diseases. Virtual screening and similarity search in combination with … tin of heinz potato saladTīmeklisRadicicol 是一种 Hsp90 抑制剂，导致蛋白酶体降解，IC50 PDK，IC50 为 230 μM (PDK1) 和 400 μM (PDK3)。Radicicol 也是一种抗真菌和抗疟疾的抗生素，通过靶向 … tino fiedlerTīmeklisradicicol Mus musculus - noncompetitive inhibitor 718760. radicicol Rattus norvegicus - noncompetitive 488220. SB-204990 Homo sapiens - - 672878, 718760. SB-204990 … tin of heinz baked beansTīmeklis2009. gada 17. nov. · The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo. Herein we report an extended library that broadly explores the structure–activity relationship (SAR) of the pochoximes with four points of diversity. Several modifications were … passion flower nutrientsTīmeklisDicţionar de sinonime, anagrame și paronime. Linkuri utile. Versiune anterioară website (2014-2024) Dicţionarul limbii române în format electronic tin of hemp