WebApr 1, 2006 · Chromatin architecture. A complete understanding of the structure–function relationships of chromatin requires extending primarily one dimensional information, … WebJan 16, 2024 · We suggest that the 3D chromatin architecture could be used as a target for re-sensitizing cancer stem cells to therapeutics. Introduction The development of many cancers involves a dedifferentiation of cellular identity with the acquisition of a stem cell-like state in a subpopulation of cancer cells.
Chromatin architecture reorganization during stem cell …
WebJan 20, 2024 · Besides the canonical microscopic observations, the chromatin architectural capture techniques, including the Hi-C and ChIA-PET, have been widely applied in characterization of chromatin architecture in various plant and animal model species, in which chromatin architectural features, such as the chromosome territory, compartment … WebNov 30, 2024 · Special Issue Information. Dear Colleagues, Cancer is a disease that involves changes in the 3D (spatial) organization of the genome impacting on chromosomal translocations, gene function (transcription, expression, replication) and cell survival. Nuclear remodeling facilitates tumor cell heterogeneity and creates the genetic diversity … featherweight singer sewing machines for sale
Chromatin Definition & Meaning - Merriam-Webster
WebSep 5, 2016 · The expression of the chimeric histone H2B-GFP causes dramatic changes in chromatin architecture, including the loss of peripheral heterochromatin, chromocenter declustering and changes in the texture of the nucleoplasm. This is likely due to stearic impediment of highly-packed tertiary chromatin fiber folding in heterochomatin by the ... WebDec 1, 2024 · Here, we combined high-throughput chromosome conformation capture (Hi-C), whole-genome sequencing (WGS) and RNA-seq data to explore the influence of the 3D architecture of chromatin on heterosis in B. napus at the seedling stage (Fig. 1 A).We revealed dynamic changes of 3D chromatin architecture between parents and F1 … WebApr 1, 2006 · The term ‘chromatin structure’ covers a wide range of phenomena and levels of organization, from the atomic details of nucleosome architecture to the large-scale nucleus-wide arrangements of interphase chromosomes. featherweight singer sewing machine for sale